| DAA1002 |
Decreased ability to modulate heat loss |
Physiological |
integument system |
Human |
— |
— |
|
| DAA1006 |
Decreased amounts of collagen IV and VII, and abnormal elastin in dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA1004 |
Decreased/disorganized fibril network of dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA991 |
Decreased function of epithelial barriers |
Physiological |
lung, oral cavity, pharynx, oesophagus, stomach, intestine, epidermis |
Human |
— |
— |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA992 |
Decrease in dermal papillae density |
Physiological |
epidermis, dermis |
Human |
— |
— |
|
| DAA2388 |
dehydrogenase/reductase (SDR family) member 3 decreases with age |
Molecular |
dermis |
Human |
DHRS3 |
15.8% Decrease DNA Methylation |
|
| DAA2588 |
Depletion of hair follicle melanocytes |
Physiological |
hair follicle |
Human |
— |
— |
|
| DAA1009 |
Dermal collagen atrophies |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2419 |
dickkopf homolog 1 precursor increases with age |
Molecular |
dermis |
Human |
DKK1 |
16.2% Increase DNA Methylation |
|
| DAA1997 |
DNA damage increases with age |
Molecular |
skin |
Human |
— |
— |
|
| DAA997 |
Elastin fibers lost from upper layers of dermis |
Physiological |
dermis |
Human |
— |
— |
|
| DAA2415 |
engrailed homolog 1 increases with age |
Molecular |
dermis |
Human |
EN1 |
18.8% Increase DNA Methylation |
|
| DAA993 |
Epidermis held less tightly to dermis |
Physiological |
epidermis |
Human |
— |
— |
|
| DAA2411 |
gelsolin-like capping protein decreases with age |
Molecular |
dermis |
Human |
CAPG |
20.1% Decrease DNA Methylation |
|
| DAA4096 |
Gene expression of AACS decreases with age |
Molecular |
skin |
Human |
AACS |
— |
|
| DAA2965 |
Gene expression of AADAC decreases with age |
Molecular |
skin |
Human |
AADAC |
— |
|
| DAA2966 |
Gene expression of ABCA1 increases with age |
Molecular |
skin |
Human |
ABCA1 |
— |
|
| DAA2967 |
Gene expression of ABCA4 decreases with age |
Molecular |
skin |
Human |
ABCA4 |
— |
|
| DAA3728 |
Gene expression of ABCA5 increases with age |
Molecular |
skin |
Human |
ABCA5 |
— |
|
| DAA3320 |
Gene expression of ABCB1 increases with age |
Molecular |
skin |
Human |
ABCB1 |
— |
|
| DAA3607 |
Gene expression of ABCC4 decreases with age |
Molecular |
skin |
Human |
ABCC4 |
— |
|
| DAA4344 |
Gene expression of ABHD12B decreases with age |
Molecular |
skin |
Human |
ABHD12B |
— |
|
| DAA3777 |
Gene expression of ABHD12 decreases with age |
Molecular |
skin |
Human |
ABHD12 |
— |
|
| DAA3760 |
Gene expression of ABHD14A decreases with age |
Molecular |
skin |
Human |
ABHD14A |
— |
|