ATP-binding cassette, sub-family B (MDR/TAP), member 1

Symbol

ABCB1 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Abcb1b Mus musculus
Abcb1a Mus musculus
Mdr49 Drosophila melanogaster
Mdr50 Drosophila melanogaster
CG10226 Drosophila melanogaster
Mdr65 Drosophila melanogaster
pgp-2 Caenorhabditis elegans
STE6 Saccharomyces cerevisiae
abcb4 Danio rerio

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0006810 transport biological_process
GO:0042493 response to drug biological_process
GO:0055085 transmembrane transport biological_process
GO:0072089 stem cell proliferation biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0016324 apical plasma membrane cellular_component
GO:0046581 intercellular canaliculus cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008559 xenobiotic-transporting ATPase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function