ATP-binding cassette, sub-family A (ABC1), member 5

Symbol

ABCA5 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Abca5 Mus musculus
Abca5 Rattus norvegicus
abca5 Danio rerio

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006810 transport biological_process
GO:0010745 negative regulation of macrophage derived foam cell differentiation biological_process
GO:0033344 cholesterol efflux biological_process
GO:0034375 high-density lipoprotein particle remodeling biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005764 lysosome cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005770 late endosome cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031902 late endosome membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016887 ATPase activity molecular_function