ATP-binding cassette, sub-family A (ABC1), member 1


ABCA1 (may also be known as: None)




The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]


abca1b Danio rerio
Abca1 Mus musculus
Abca1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002790 peptide secretion biological_process
GO:0006497 protein lipidation biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006810 transport biological_process
GO:0006820 anion transport biological_process
GO:0006911 phagocytosis, engulfment biological_process
GO:0007040 lysosome organization biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0010745 negative regulation of macrophage derived foam cell differentiation biological_process
GO:0010875 positive regulation of cholesterol efflux biological_process
GO:0010887 negative regulation of cholesterol storage biological_process
GO:0016197 endosome transport biological_process
GO:0030819 positive regulation of cAMP biosynthetic process biological_process
GO:0032367 intracellular cholesterol transport biological_process
GO:0032488 Cdc42 protein signal transduction biological_process
GO:0033344 cholesterol efflux biological_process
GO:0033700 phospholipid efflux biological_process
GO:0034380 high-density lipoprotein particle assembly biological_process
GO:0034616 response to laminar fluid shear stress biological_process
GO:0038027 apolipoprotein A-I-mediated signaling pathway biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045332 phospholipid translocation biological_process
GO:0050702 interleukin-1 beta secretion biological_process
GO:0055091 phospholipid homeostasis biological_process
GO:0055098 response to low-density lipoprotein particle stimulus biological_process
GO:0060155 platelet dense granule organization biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0005622 intracellular cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0030139 endocytic vesicle cellular_component
GO:0045121 membrane raft cellular_component
GO:0045335 phagocytic vesicle cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0005543 phospholipid binding molecular_function
GO:0005548 phospholipid transporter activity molecular_function
GO:0008509 anion transmembrane transporter activity molecular_function
GO:0015485 cholesterol binding molecular_function
GO:0016887 ATPase activity molecular_function
GO:0017127 cholesterol transporter activity molecular_function
GO:0019905 syntaxin binding molecular_function
GO:0031267 small GTPase binding molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0034186 apolipoprotein A-I binding molecular_function
GO:0034188 apolipoprotein A-I receptor activity molecular_function