dickkopf 1 homolog (Xenopus laevis)

Symbol

DKK1 (may also be known as: None)

Organism

Human

Description

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
dkk1b Danio rerio
Dkk1 Mus musculus
Dkk1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2419 dickkopf homolog 1 precursor increases with age Molecular dermis Human DKK1 16.2% Increase DNA Methylation
DAA3694 Gene expression of DKK1 decreases with age Molecular skin Human DKK1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000904 cell morphogenesis involved in differentiation biological_process
GO:0001706 endoderm formation biological_process
GO:0001707 mesoderm formation biological_process
GO:0001942 hair follicle development biological_process
GO:0002090 regulation of receptor internalization biological_process
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0030326 embryonic limb morphogenesis biological_process
GO:0030514 negative regulation of BMP signaling pathway biological_process
GO:0030900 forebrain development biological_process
GO:0031333 negative regulation of protein complex assembly biological_process
GO:0032526 response to retinoic acid biological_process
GO:0033137 negative regulation of peptidyl-serine phosphorylation biological_process
GO:0048642 negative regulation of skeletal muscle tissue development biological_process
GO:0060325 face morphogenesis biological_process
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway biological_process
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway biological_process
GO:0090244 Wnt receptor signaling pathway involved in somitogenesis biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008083 growth factor activity molecular_function
GO:0048019 receptor antagonist activity molecular_function
GO:0050750 low-density lipoprotein particle receptor binding molecular_function