ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Symbol

ABCC4 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
CG7627 Drosophila melanogaster
CG31792 Drosophila melanogaster
CG9270 Drosophila melanogaster
CG10505 Drosophila melanogaster
Mrp4 Drosophila melanogaster
CG4562 Drosophila melanogaster
CG5789 Drosophila melanogaster
CG11897 Drosophila melanogaster
CG11898 Drosophila melanogaster
l(2)03659 Drosophila melanogaster
Abcc4 Rattus norvegicus
Abcc4 Mus musculus
CG31793 Drosophila melanogaster
abcc4 Danio rerio
YCF1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002576 platelet degranulation biological_process
GO:0006811 ion transport biological_process
GO:0007596 blood coagulation biological_process
GO:0008150 biological_process biological_process
GO:0030168 platelet activation biological_process
GO:0055085 transmembrane transport biological_process
GO:0005624 membrane fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031088 platelet dense granule membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005254 chloride channel activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function