ATP-binding cassette, sub-family C (CFTR/MRP), member 4


ABCC4 (may also be known as: None)




The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]


CG9270 Drosophila melanogaster
abcc4 Danio rerio
Abcc4 Mus musculus
Abcc4 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002576 platelet degranulation biological_process
GO:0006811 ion transport biological_process
GO:0007596 blood coagulation biological_process
GO:0008150 biological_process biological_process
GO:0030168 platelet activation biological_process
GO:0055085 transmembrane transport biological_process
GO:0005624 membrane fraction cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031088 platelet dense granule membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005254 chloride channel activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function