ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Symbol
ABCC4
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CG9270 | Drosophila melanogaster | |
| abcc4 | Danio rerio | |
| Abcc4 | Mus musculus | |
| Abcc4 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002576 | platelet degranulation | biological_process | |
| GO:0006811 | ion transport | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0008150 | biological_process | biological_process | |
| GO:0030168 | platelet activation | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0005624 | membrane fraction | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0031088 | platelet dense granule membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0005254 | chloride channel activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | molecular_function | |
| GO:0016887 | ATPase activity | molecular_function | |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | molecular_function | |