Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed) (248 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA2249 NLR family, pyrin domain containing 1 decreases with age Molecular frontal lobe Human NLRP1 29.4% Decrease Gene Expression Level
DAA2265 NLR family, pyrin domain containing 1 decreases with age Molecular parietal lobe Human NLRP1 24.8% Decrease Gene Expression Level
DAA2247 pannexin 1 decreases with age Molecular frontal lobe Human PANX1 59.9% Decrease Gene Expression Level
DAA2258 pannexin 1 decreases with age Molecular parietal lobe Human PANX1 50.0% Decrease Gene Expression Level
DAA2268 pannexin 1 decreases with age Molecular temporal lobe Human PANX1 41.6% Decrease Gene Expression Level
DAA2353 Pannexin 2 decreases with age Molecular temporal lobe Human PANX2 16.5% Decrease Gene Expression Level
DAA2352 Pannexin 2 decreases with age Molecular hippocampus Human PANX2 19.1% Decrease Gene Expression Level
DAA2351 Pannexin 2 decreases with age Molecular frontal lobe Human PANX2 8.1% Decrease Gene Expression Level
DAA2206 S100 calcium binding protein A8 increases with age Molecular temporal lobe Human S100A8 530.6% Increase Gene Expression Level
DAA2243 S100 calcium binding protein A8 increases with age Molecular frontal lobe Human S100A8 921.4% Increase Gene Expression Level
DAA2217 S100 calcium binding protein A8 increases with age Molecular hippocampus Human S100A8 1115.4% Increase Gene Expression Level
DAA2231 S100 calcium binding protein A8 increases with age Molecular parietal lobe Human S100A8 1228.2% Increase Gene Expression Level
DAA2244 S100 calcium binding protein A9 increases with age Molecular frontal lobe Human S100A9 92.8% Increase Gene Expression Level
DAA2232 S100 calcium binding protein A9 increases with age Molecular parietal lobe Human S100A9 229.0% Increase Gene Expression Level
DAA2266 Thioredoxin interacting protein increases with age Molecular temporal lobe Human TXNIP 146.6% Increase Gene Expression Level
DAA2246 Thioredoxin interacting protein increases with age Molecular frontal lobe Human TXNIP 250.2% Increase Gene Expression Level
DAA2245 Thioredoxin interacting protein increases with age Molecular frontal lobe Human TXNIP 277.8% Increase Gene Expression Level
DAA2267 Thioredoxin interacting protein increases with age Molecular temporal lobe Human TXNIP 130.7% Increase Gene Expression Level
DAA2257 Thioredoxin interacting protein increases with age Molecular parietal lobe Human TXNIP 124.8% Increase Gene Expression Level
DAA2256 Thioredoxin interacting protein increases with age Molecular parietal lobe Human TXNIP 143.1% Increase Gene Expression Level
DAA2219 toll interacting protein decreases with age Molecular parietal lobe Human TOLLIP 53.6% Decrease Gene Expression Level
DAA2218 toll interacting protein decreases with age Molecular parietal lobe Human TOLLIP 61.5% Decrease Gene Expression Level
DAA2235 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 36.3% Decrease Gene Expression Level
DAA2233 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 59.5% Decrease Gene Expression Level
DAA2234 toll interacting protein decreases with age Molecular frontal lobe Human TOLLIP 57.8% Decrease Gene Expression Level