pannexin 1


PANX1 (may also be known as: None)




The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]


panx1a Danio rerio
Panx1 Mus musculus
Panx1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2247 pannexin 1 decreases with age Molecular frontal lobe Human PANX1 59.9% Decrease Gene Expression Level
DAA2258 pannexin 1 decreases with age Molecular parietal lobe Human PANX1 50.0% Decrease Gene Expression Level
DAA2268 pannexin 1 decreases with age Molecular temporal lobe Human PANX1 41.6% Decrease Gene Expression Level

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1803 pannexin 1 Molecular muscle Mouse Panx1 28.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006812 cation transport biological_process
GO:0006816 calcium ion transport biological_process
GO:0007268 synaptic transmission biological_process
GO:0033198 response to ATP biological_process
GO:0034214 protein hexamerization biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0045087 innate immune response biological_process
GO:0050715 positive regulation of cytokine secretion biological_process
GO:0050717 positive regulation of interleukin-1 alpha secretion biological_process
GO:0050718 positive regulation of interleukin-1 beta secretion biological_process
GO:0070588 calcium ion transmembrane transport biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005921 gap junction cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0032059 bleb cellular_component
GO:0005102 receptor binding molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005262 calcium channel activity molecular_function
GO:0022840 leak channel activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0055077 gap junction hemi-channel activity molecular_function