Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed) (248 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA2364 major histocompatibility complex, class II, DR alpha increases with age Molecular parietal lobe Human HLA-DRA 303.7% Increase Gene Expression Level
DAA2369 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 135.3% Increase Gene Expression Level
DAA2135 major histocompatibility complex, class II, DR beta 1 increases with age Molecular hippocampus Human HLA-DRB1 193.5% Increase Gene Expression Level
DAA2137 major histocompatibility complex, class II, DR beta 1 increases with age Molecular frontal lobe Human HLA-DRB1 83.0% Increase Gene Expression Level
DAA2136 major histocompatibility complex, class II, DR beta 1 increases with age Molecular parietal lobe Human HLA-DRB1 90.3% Increase Gene Expression Level
DAA2360 major histocompatibility complex, class II, DR beta 1 increases with age Molecular hippocampus Human HLA-DRB1 204.2% Increase Gene Expression Level
DAA2365 major histocompatibility complex, class II, DR beta 1 increases with age Molecular parietal lobe Human HLA-DRB1 111.1% Increase Gene Expression Level
DAA2370 major histocompatibility complex, class II, DR beta 1 increases with age Molecular frontal lobe Human HLA-DRB1 84.8% Increase Gene Expression Level
DAA2361 major histocompatibility complex, class II, DR beta 4 increases with age Molecular hippocampus Human HLA-DRB4 177.7% Increase Gene Expression Level
DAA2371 major histocompatibility complex, class II, DR beta 4 increases with age Molecular frontal lobe Human HLA-DRB4 88.5% Increase Gene Expression Level
DAA2366 major histocompatibility complex, class II, DR beta 4 increases with age Molecular parietal lobe Human HLA-DRB4 100.4% Increase Gene Expression Level
DAA2367 major histocompatibility complex, class II, DR beta 5 increases with age Molecular parietal lobe Human HLA-DRB5 95.8% Increase Gene Expression Level
DAA2362 major histocompatibility complex, class II, DR beta 5 increases with age Molecular hippocampus Human HLA-DRB5 184.0% Increase Gene Expression Level
DAA2372 major histocompatibility complex, class II, DR beta 5 increases with age Molecular frontal lobe Human HLA-DRB5 64.1% Increase Gene Expression Level
DAA2163 major histocompatibility complex, class II, DR beta 6 increases with age Molecular hippocampus Human HLA-DRB6 150.2% Increase Gene Expression Level
DAA2164 major histocompatibility complex, class II, DR beta 6 increases with age Molecular parietal lobe Human HLA-DRB6 33.5% Increase Gene Expression Level
DAA2335 major histocompatibility complex, class I-related increases with age Molecular hippocampus Human MR1 46.6% Increase Gene Expression Level
DAA2349 major histocompatibility complex, class I-related increases with age Molecular frontal lobe Human MR1 22.4% Increase Gene Expression Level
DAA2350 major histocompatibility complex, class I-related increases with age Molecular frontal lobe Human MR1 32.2% Increase Gene Expression Level
DAA2165 MHC class I polypeptide-related sequence A increases with age Molecular frontal lobe Human MICA 39.5% Increase Gene Expression Level
DAA2348 MHC class I polypeptide-related sequence A increases with age Molecular frontal lobe Human MICA 37.9% Increase Gene Expression Level
DAA2340 MHC class I polypeptide-related sequence B increases with age Molecular parietal lobe Human MICB 39.9% Increase Gene Expression Level
DAA2216 myeloid differentiation primary response gene (88) increases with age Molecular hippocampus Human MYD88 59.3% Increase Gene Expression Level
DAA2230 myeloid differentiation primary response gene (88) increases with age Molecular parietal lobe Human MYD88 54.8% Increase Gene Expression Level
DAA2242 myeloid differentiation primary response gene (88) increases with age Molecular frontal lobe Human MYD88 58.7% Increase Gene Expression Level