NLR family, pyrin domain containing 1


NLRP1 (may also be known as: None)




This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]


Nlrp1b Mus musculus
Nlrp1b Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3681 Gene expression of NLRP1 increases with age Molecular skin Human NLRP1
DAA2249 NLR family, pyrin domain containing 1 decreases with age Molecular frontal lobe Human NLRP1 29.4% Decrease Gene Expression Level
DAA2265 NLR family, pyrin domain containing 1 decreases with age Molecular parietal lobe Human NLRP1 24.8% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006952 defense response biological_process
GO:0032495 response to muramyl dipeptide biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042742 defense response to bacterium biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0045087 innate immune response biological_process
GO:0050718 positive regulation of interleukin-1 beta secretion biological_process
GO:0050727 regulation of inflammatory response biological_process
GO:0051402 neuron apoptosis biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0072558 NLRP1 inflammasome complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019904 protein domain specific binding molecular_function