Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed) (248 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA2153 complement component 4A increases with age Molecular frontal lobe Human C4A 187.3% Increase Gene Expression Level
DAA2326 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 146.8% Increase Gene Expression Level
DAA2369 major histocompatibility complex, class II, DR alpha increases with age Molecular frontal lobe Human HLA-DRA 135.3% Increase Gene Expression Level
DAA2307 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular frontal lobe Human CX3CL1 61.1% Decrease Gene Expression Level
DAA2308 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular frontal lobe Human CX3CL1 58.0% Decrease Gene Expression Level
DAA2248 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular frontal lobe Human CASP1 30.2% Increase Gene Expression Level
DAA2195 complement component 1, q subcomponent, B chain increases with age Molecular frontal lobe Human C1QB 166.8% Increase Gene Expression Level
DAA2289 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide increases with age Molecular frontal lobe Human FCER1G 105.3% Increase Gene Expression Level
DAA2309 chemokine (C-X-C motif) ligand 16 increases with age Molecular frontal lobe Human CXCL16 44.1% Increase Gene Expression Level
DAA2144 Fc fragment of IgG, high affinity Ia, receptor (CD64) increases with age Molecular frontal lobe Human FCGR1A 157.3% Increase Gene Expression Level
DAA2145 Fc fragment of IgG, high affinity Ib, receptor (CD64) increases with age Molecular frontal lobe Human FCGR1B 170.4% Increase Gene Expression Level
DAA2196 complement component 1, q subcomponent, C chain increases with age Molecular frontal lobe Human C1QC 126.1% Increase Gene Expression Level
DAA2162 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) increases with age Molecular frontal lobe Human FCGR3B 261.1% Increase Gene Expression Level
DAA2287 CD163 molecule increases with age Molecular frontal lobe Human CD163 283.0% Increase Gene Expression Level
DAA2197 complement component 1, s subcomponent increases with age Molecular frontal lobe Human C1S 71.9% Increase Gene Expression Level
DAA2288 CD163 molecule increases with age Molecular frontal lobe Human CD163 383.1% Increase Gene Expression Level
DAA2379 major histocompatibility complex, class I, B increases with age Molecular frontal lobe Human HLA-B 39.0% Increase Gene Expression Level
DAA2202 Clusterin increases with age Molecular frontal lobe Human CLU 30.9% Increase Gene Expression Level
DAA2203 Clusterin increases with age Molecular frontal lobe Human CLU 56.5% Increase Gene Expression Level
DAA2201 Clusterin increases with age Molecular frontal lobe Human CLU 25.5% Increase Gene Expression Level
DAA2380 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 56.5% Increase Gene Expression Level
DAA2154 complement component 4B increases with age Molecular frontal lobe Human C4B 895.9% Increase Gene Expression Level
DAA2194 complement component 1, q subcomponent, A chain increases with age Molecular frontal lobe Human C1QA 98.4% Increase Gene Expression Level
DAA2349 major histocompatibility complex, class I-related increases with age Molecular frontal lobe Human MR1 22.4% Increase Gene Expression Level
DAA2372 major histocompatibility complex, class II, DR beta 5 increases with age Molecular frontal lobe Human HLA-DRB5 64.1% Increase Gene Expression Level