major histocompatibility complex, class I, C

Symbol

HLA-C (may also be known as: None)

Organism

Human

Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2382 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 44.0% Increase Gene Expression Level
DAA2378 major histocompatibility complex, class I, C increases with age Molecular parietal lobe Human HLA-C 37.0% Increase Gene Expression Level
DAA2328 major histocompatibility complex, class I, C increases with age Molecular hippocampus Human HLA-C 32.6% Increase Gene Expression Level
DAA2336 major histocompatibility complex, class I, C increases with age Molecular parietal lobe Human HLA-C 37.7% Increase Gene Expression Level
DAA2342 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 40.1% Increase Gene Expression Level
DAA2374 major histocompatibility complex, class I, C increases with age Molecular hippocampus Human HLA-C 38.9% Increase Gene Expression Level
DAA2375 major histocompatibility complex, class I, C increases with age Molecular hippocampus Human HLA-C 37.8% Increase Gene Expression Level
DAA2376 major histocompatibility complex, class I, C increases with age Molecular hippocampus Human HLA-C 39.8% Increase Gene Expression Level
DAA2377 major histocompatibility complex, class I, C increases with age Molecular parietal lobe Human HLA-C 34.9% Increase Gene Expression Level
DAA2380 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 56.5% Increase Gene Expression Level
DAA2381 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 32.8% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent biological_process
GO:0006955 immune response biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0050776 regulation of immune response biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0060337 type I interferon-mediated signaling pathway biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0012507 ER to Golgi transport vesicle membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030670 phagocytic vesicle membrane cellular_component
GO:0031901 early endosome membrane cellular_component
GO:0042612 MHC class I protein complex cellular_component
GO:0071556 integral to lumenal side of endoplasmic reticulum membrane cellular_component
GO:0032393 MHC class I receptor activity molecular_function