complement component 1, q subcomponent, B chain

Symbol

C1QB (may also be known as: None)

Organism

Human

Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
c1qc Danio rerio
C1qb Mus musculus
C1qb Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2195 complement component 1, q subcomponent, B chain increases with age Molecular frontal lobe Human C1QB 166.8% Increase Gene Expression Level
DAA2182 complement component 1, q subcomponent, B chain increases with age Molecular parietal lobe Human C1QB 288.1% Increase Gene Expression Level
DAA2170 complement component 1, q subcomponent, B chain increases with age Molecular hippocampus Human C1QB 391.4% Increase Gene Expression Level
DAA2166 complement component 1, q subcomponent, B chain increases with age Molecular temporal lobe Human C1QB 186.7% Increase Gene Expression Level
DAA3017 Gene expression of C1QB decreases with age Molecular skin Human C1QB

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1491 complement component 1, q subcomponent, beta polypeptide Molecular kidney Mouse C1qb 9.0% Increase Gene Expression Level
DAA1398 complement component 1, q subcomponent, beta polypeptide Molecular hippocampus Mouse C1qb 3.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006956 complement activation biological_process
GO:0006958 complement activation, classical pathway biological_process
GO:0007420 brain development biological_process
GO:0007568 aging biological_process
GO:0010033 response to organic substance biological_process
GO:0045087 innate immune response biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005581 collagen cellular_component
GO:0005602 complement component C1 complex cellular_component
GO:0042803 protein homodimerization activity molecular_function