complement component 1, q subcomponent, A chain

Symbol

C1QA (may also be known as: None)

Organism

Human

Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
C1qa Mus musculus
C1qa Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2194 complement component 1, q subcomponent, A chain increases with age Molecular frontal lobe Human C1QA 98.4% Increase Gene Expression Level
DAA2181 complement component 1, q subcomponent, A chain increases with age Molecular parietal lobe Human C1QA 154.9% Increase Gene Expression Level
DAA2169 complement component 1, q subcomponent, A chain increases with age Molecular hippocampus Human C1QA 243.4% Increase Gene Expression Level
DAA3016 Gene expression of C1QA decreases with age Molecular skin Human C1QA

Changes associated with the orthologs of this gene

GO Terms

GO IDGO TermGO Category
GO:0006956 complement activation biological_process
GO:0006958 complement activation, classical pathway biological_process
GO:0007267 cell-cell signaling biological_process
GO:0045087 innate immune response biological_process
GO:0005576 extracellular region cellular_component
GO:0005581 collagen cellular_component
GO:0005602 complement component C1 complex cellular_component