clusterin

Symbol

CLU (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

Orthologs

SymbolSpecies
clu Danio rerio
Clu Mus musculus
Clu Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2201 Clusterin increases with age Molecular frontal lobe Human CLU 25.5% Increase Gene Expression Level
DAA2203 Clusterin increases with age Molecular frontal lobe Human CLU 56.5% Increase Gene Expression Level
DAA2202 Clusterin increases with age Molecular frontal lobe Human CLU 30.9% Increase Gene Expression Level
DAA2193 Clusterin increases with age Molecular parietal lobe Human CLU 47.9% Increase Gene Expression Level
DAA2192 Clusterin increases with age Molecular parietal lobe Human CLU 23.5% Increase Gene Expression Level
DAA2191 Clusterin increases with age Molecular parietal lobe Human CLU 22.5% Increase Gene Expression Level
DAA2180 Clusterin increases with age Molecular hippocampus Human CLU 58.9% Increase Gene Expression Level
DAA2179 Clusterin increases with age Molecular hippocampus Human CLU 41.7% Increase Gene Expression Level
DAA2178 Clusterin increases with age Molecular hippocampus Human CLU 33.1% Increase Gene Expression Level
DAA2168 Clusterin increases with age Molecular temporal lobe Human CLU 25.9% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001836 release of cytochrome c from mitochondria biological_process
GO:0002576 platelet degranulation biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006956 complement activation biological_process
GO:0006958 complement activation, classical pathway biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007596 blood coagulation biological_process
GO:0008219 cell death biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0009611 response to wounding biological_process
GO:0009615 response to virus biological_process
GO:0030168 platelet activation biological_process
GO:0031018 endocrine pancreas development biological_process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0032463 negative regulation of protein homooligomerization biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0045087 innate immune response biological_process
GO:0045597 positive regulation of cell differentiation biological_process
GO:0048812 neuron projection morphogenesis biological_process
GO:0050821 protein stabilization biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051788 response to misfolded protein biological_process
GO:0061077 chaperone-mediated protein folding biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0016235 aggresome cellular_component
GO:0030426 growth cone cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0031093 platelet alpha granule lumen cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0034366 spherical high-density lipoprotein particle cellular_component
GO:0042583 chromaffin granule cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0005515 protein binding molecular_function
GO:0016887 ATPase activity molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0051787 misfolded protein binding molecular_function