AT rich interactive domain 1A (SWI-like)


ARID1A (may also be known as: None)




This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


arid1ab Danio rerio
Arid1a Mus musculus
Arid1a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2082 AT rich interactive domain 1A (SWI-like) increases with age Molecular ovary Human ARID1A 51.0% Increase Gene Expression Level
DAA2083 AT rich interactive domain 1A (SWI-like) increases with age Molecular ovary Human ARID1A 103.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006325 chromatin organization biological_process
GO:0006337 nucleosome disassembly biological_process
GO:0006338 chromatin remodeling biological_process
GO:0006357 regulation of transcription from RNA polymerase II promoter biological_process
GO:0007399 nervous system development biological_process
GO:0030520 intracellular estrogen receptor signaling pathway biological_process
GO:0030521 androgen receptor signaling pathway biological_process
GO:0042766 nucleosome mobilization biological_process
GO:0042921 glucocorticoid receptor signaling pathway biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048096 chromatin-mediated maintenance of transcription biological_process
GO:0000790 nuclear chromatin cellular_component
GO:0005622 intracellular cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0016514 SWI/SNF complex cellular_component
GO:0071564 npBAF complex cellular_component
GO:0071565 nBAF complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016922 ligand-dependent nuclear receptor binding molecular_function