RAN, member RAS oncogene family


RAN (may also be known as: None)




RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]


ran-1 Caenorhabditis elegans
ran Drosophila melanogaster
ran Danio rerio
Ran Mus musculus
Ran Rattus norvegicus
GSP2 Saccharomyces cerevisiae
spi1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2077 RAN, member RAS oncogene family decreases with age Molecular ovary Human RAN 40.1% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006184 GTP catabolic process biological_process
GO:0006259 DNA metabolic process biological_process
GO:0006405 RNA export from nucleus biological_process
GO:0006606 protein import into nucleus biological_process
GO:0006611 protein export from nucleus biological_process
GO:0006886 intracellular protein transport biological_process
GO:0006913 nucleocytoplasmic transport biological_process
GO:0007049 cell cycle biological_process
GO:0007052 mitotic spindle organization biological_process
GO:0007067 mitosis biological_process
GO:0007165 signal transduction biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0016032 viral reproduction biological_process
GO:0019058 viral infectious cycle biological_process
GO:0030521 androgen receptor signaling pathway biological_process
GO:0032092 positive regulation of protein binding biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0046796 viral genome transport in host cell biological_process
GO:0051301 cell division biological_process
GO:0000785 chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005643 nuclear pore cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0042470 melanosome cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005525 GTP binding molecular_function
GO:0050681 androgen receptor binding molecular_function