protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Symbol
Organism
Description
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2394 | AMP-activated protein kinase; non-catalytic gamma-3 subunit decreases with age | Molecular | dermis | Human | PRKAG3 | 17.8% Decrease DNA Methylation | |
| DAA2395 | AMP-activated protein kinase; non-catalytic gamma-3 subunit decreases with age | Molecular | dermis | Human | PRKAG3 | 20.1% Decrease DNA Methylation | |
| DAA2443 | AMP-activated protein kinase; non-catalytic gamma-3 subunit decreases with age | Molecular | mesenchymal stem cell | Human | PRKAG3 | 15.1% Decrease DNA Methylation | |
| DAA2444 | AMP-activated protein kinase; non-catalytic gamma-3 subunit decreases with age | Molecular | mesenchymal stem cell | Human | PRKAG3 | 20.1% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005978 | glycogen biosynthetic process | biological_process | |
| GO:0006633 | fatty acid biosynthetic process | biological_process | |
| GO:0007050 | cell cycle arrest | biological_process | |
| GO:0007243 | intracellular protein kinase cascade | biological_process | |
| GO:0008286 | insulin receptor signaling pathway | biological_process | |
| GO:0015758 | glucose transport | biological_process | |
| GO:0046320 | regulation of fatty acid oxidation | biological_process | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0031588 | AMP-activated protein kinase complex | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004679 | AMP-activated protein kinase activity | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0016301 | kinase activity | molecular_function | |
| GO:0019901 | protein kinase binding | molecular_function | |