protein kinase, AMP-activated, gamma 3 non-catalytic subunit


PRKAG3 (may also be known as: None)




The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0005978 glycogen biosynthetic process biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007243 intracellular protein kinase cascade biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0015758 glucose transport biological_process
GO:0046320 regulation of fatty acid oxidation biological_process
GO:0005829 cytosol cellular_component
GO:0031588 AMP-activated protein kinase complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004679 AMP-activated protein kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0019901 protein kinase binding molecular_function