complement factor H
Symbol
CFH
(may also be known as: None)
Organism
Human
Description
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| cfhl2 | Danio rerio | |
| Cfh | Mus musculus | |
| Cfh | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2177 | complement factor H increases with age | Molecular | hippocampus | Human | CFH | 166.8% Increase Gene Expression Level | |
| DAA2190 | complement factor H increases with age | Molecular | parietal lobe | Human | CFH | 138.9% Increase Gene Expression Level | |
| DAA2200 | complement factor H increases with age | Molecular | frontal lobe | Human | CFH | 210.8% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0006956 | complement activation | biological_process |
| GO:0006957 | complement activation, alternative pathway | biological_process |
| GO:0005576 | extracellular region | cellular_component |
| GO:0005615 | extracellular space | cellular_component |