complement factor H


CFH (may also be known as: None)




This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]


cfhl2 Danio rerio
Cfh Mus musculus
Cfh Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2177 complement factor H increases with age Molecular hippocampus Human CFH 166.8% Increase Gene Expression Level
DAA2190 complement factor H increases with age Molecular parietal lobe Human CFH 138.9% Increase Gene Expression Level
DAA2200 complement factor H increases with age Molecular frontal lobe Human CFH 210.8% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006956 complement activation biological_process
GO:0006957 complement activation, alternative pathway biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component