F-box and leucine-rich repeat protein 16


FBXL16 (may also be known as: None)




Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]


CG32085-RA Drosophila melanogaster
si:dkey-20j1.3 Danio rerio
Fbxl16 Mus musculus
Fbxl16 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2123 F-box and leucine-rich repeat protein 16 decreases with age Molecular ovary Human FBXL16 51.7% Decrease Gene Expression Level