Cribbs et al. (2012) "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study." J Neuroinflammation 9:179 (PubMed) (248 entries)

Changes associated with this reference

Identifier Name Type Tissues Organism Gene Data Actions
DAA2379 major histocompatibility complex, class I, B increases with age Molecular frontal lobe Human HLA-B 39.0% Increase Gene Expression Level
DAA2195 complement component 1, q subcomponent, B chain increases with age Molecular frontal lobe Human C1QB 166.8% Increase Gene Expression Level
DAA2341 major histocompatibility complex, class I, B increases with age Molecular frontal lobe Human HLA-B 36.5% Increase Gene Expression Level
DAA2144 Fc fragment of IgG, high affinity Ia, receptor (CD64) increases with age Molecular frontal lobe Human FCGR1A 157.3% Increase Gene Expression Level
DAA2292 Fc fragment of IgG, low affinity IIa, receptor (CD32) increases with age Molecular frontal lobe Human FCGR2A 104.3% Increase Gene Expression Level
DAA2196 complement component 1, q subcomponent, C chain increases with age Molecular frontal lobe Human C1QC 126.1% Increase Gene Expression Level
DAA2237 toll-like receptor 2 increases with age Molecular frontal lobe Human TLR2 155.6% Increase Gene Expression Level
DAA2239 toll-like receptor 4 increases with age Molecular frontal lobe Human TLR4 150.9% Increase Gene Expression Level
DAA2307 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular frontal lobe Human CX3CL1 61.1% Decrease Gene Expression Level
DAA2236 CD14 molecule increases with age Molecular frontal lobe Human CD14 134.9% Increase Gene Expression Level
DAA2197 complement component 1, s subcomponent increases with age Molecular frontal lobe Human C1S 71.9% Increase Gene Expression Level
DAA2308 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular frontal lobe Human CX3CL1 58.0% Decrease Gene Expression Level
DAA2248 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular frontal lobe Human CASP1 30.2% Increase Gene Expression Level
DAA2198 complement component 3a receptor 1 increases with age Molecular frontal lobe Human C3AR1 89.0% Increase Gene Expression Level
DAA2154 complement component 4B increases with age Molecular frontal lobe Human C4B 895.9% Increase Gene Expression Level
DAA2294 Fc fragment of IgG, receptor, transporter, alpha increases with age Molecular frontal lobe Human FCGRT 89.3% Increase Gene Expression Level
DAA2200 complement factor H increases with age Molecular frontal lobe Human CFH 210.8% Increase Gene Expression Level
DAA2381 major histocompatibility complex, class I, C increases with age Molecular frontal lobe Human HLA-C 32.8% Increase Gene Expression Level
DAA2309 chemokine (C-X-C motif) ligand 16 increases with age Molecular frontal lobe Human CXCL16 44.1% Increase Gene Expression Level
DAA2185 complement component 1, s subcomponent increases with age Molecular parietal lobe Human C1S 60.4% Increase Gene Expression Level
DAA2184 complement component 1, s subcomponent increases with age Molecular parietal lobe Human C1S 54.0% Increase Gene Expression Level
DAA2284 Fc fragment of IgG, low affinity IIa, receptor (CD32) increases with age Molecular parietal lobe Human FCGR2A 141.5% Increase Gene Expression Level
DAA2221 CD14 molecule increases with age Molecular parietal lobe Human CD14 186.5% Increase Gene Expression Level
DAA2305 chemokine (C-X3-C motif) ligand 1 decreases with age Molecular parietal lobe Human CX3CL1 56.2% Decrease Gene Expression Level
DAA2259 Caspase 1, (interleukin 1, beta, convertase) increases with age Molecular parietal lobe Human CASP1 42.0% Increase Gene Expression Level