DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA2041 |
Altered brain mitochondrial metabolism |
Physiological |
brain |
Human |
— |
— |
|
DAA715 |
Lipid biosynthesis decreases |
Physiological |
central nervous system |
Human |
— |
— |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA731 |
Mean diffusivity increases and water diffusion anisotropy decreases |
Physiological |
corpus callosum, white matter |
Human |
— |
— |
|
DAA732 |
Glial cell number |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA744 |
EEG alterations during auditory test |
Physiological |
brain |
Human |
— |
— |
|
DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA764 |
Depolarization of mitochondria |
Physiological |
brain |
Human |
— |
— |
|
DAA726 |
Demyelination |
Physiological |
white matter |
Human |
— |
— |
|
DAA762 |
Down regulation of calcium clearance from nerve cells |
Physiological |
brain |
Human |
— |
— |
|
DAA729 |
Gray matter volume decreases |
Physiological |
grey matter |
Human |
— |
— |
|
DAA1996 |
Beta-amyloid protein deposition increases |
Physiological |
brain |
Human |
APP |
— |
|
DAA728 |
Brain matter volume declines |
Physiological |
brain |
Human |
— |
— |
|
DAA1217 |
Brain volume decrease |
Physiological |
brain |
Human |
— |
— |
|
DAA1993 |
Brain volume decreases in a regional-specific way |
Physiological |
brain |
Human |
— |
— |
|
DAA717 |
Dendrite regression, reduction in dendrite length |
Physiological |
brain |
Human |
— |
— |
|
DAA765 |
Calcium binding capacity decreases in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA2596 |
Frequency of mitochondrial DNA deletions increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA2595 |
Frequency of somatic mitochondrial mutations increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA740 |
Cortical plasticity decreases |
Physiological |
brain |
Human |
— |
— |
|
DAA727 |
Axon loss |
Physiological |
white matter |
Human |
— |
— |
|
DAA738 |
Cerebral spinal fluid amount increases |
Physiological |
brain |
Human |
— |
— |
|
DAA787 |
Increased bilateral anterior frontal activity in memory interference tests |
Physiological |
brain |
Human |
— |
— |
|