cytidine deaminase
Symbol
CDA
(may also be known as: None)
Organism
Human
Description
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| cdd-1 | Caenorhabditis elegans | |
| CG8353 | Drosophila melanogaster | |
| cda | Danio rerio | |
| Cda | Mus musculus | |
| Cda | Rattus norvegicus | |
| CDD1 | Saccharomyces cerevisiae | |
| pcd1 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006206 | pyrimidine base metabolic process | biological_process | |
| GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
| GO:0008655 | pyrimidine-containing compound salvage | biological_process | |
| GO:0009972 | cytidine deamination | biological_process | |
| GO:0019858 | cytosine metabolic process | biological_process | |
| GO:0030308 | negative regulation of cell growth | biological_process | |
| GO:0043097 | pyrimidine nucleoside salvage | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0045980 | negative regulation of nucleotide metabolic process | biological_process | |
| GO:0046898 | response to cycloheximide | biological_process | |
| GO:0051289 | protein homotetramerization | biological_process | |
| GO:0055086 | nucleobase-containing small molecule metabolic process | biological_process | |
| GO:0071217 | cellular response to external biotic stimulus | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0001882 | nucleoside binding | molecular_function | |
| GO:0004126 | cytidine deaminase activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |