scavenger receptor class B, member 1

Symbol

SCARB1 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Orthologs

SymbolSpecies
emp Drosophila melanogaster
scarb1 Danio rerio
Scarb1 Mus musculus
Scarb1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3039 Gene expression of SCARB1 decreases with age Molecular skin Human SCARB1 —

GO Terms

GO IDGO TermGO Category
GO:0001935 endothelial cell proliferation biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006702 androgen biosynthetic process biological_process
GO:0006707 cholesterol catabolic process biological_process
GO:0006810 transport biological_process
GO:0007155 cell adhesion biological_process
GO:0010595 positive regulation of endothelial cell migration biological_process
GO:0010867 positive regulation of triglyceride biosynthetic process biological_process
GO:0010886 positive regulation of cholesterol storage biological_process
GO:0010899 regulation of phosphatidylcholine catabolic process biological_process
GO:0015914 phospholipid transport biological_process
GO:0015920 lipopolysaccharide transport biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032497 detection of lipopolysaccharide biological_process
GO:0033344 cholesterol efflux biological_process
GO:0034375 high-density lipoprotein particle remodeling biological_process
GO:0034383 low-density lipoprotein particle clearance biological_process
GO:0034384 high-density lipoprotein particle clearance biological_process
GO:0042060 wound healing biological_process
GO:0042157 lipoprotein metabolic process biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0043534 blood vessel endothelial cell migration biological_process
GO:0043654 recognition of apoptotic cell biological_process
GO:0043691 reverse cholesterol transport biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0050764 regulation of phagocytosis biological_process
GO:0051000 positive regulation of nitric-oxide synthase activity biological_process
GO:0051856 adhesion to symbiont biological_process
GO:0070328 triglyceride homeostasis biological_process
GO:0070508 cholesterol import biological_process
GO:0000299 integral to membrane of membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0005901 caveola cellular_component
GO:0009986 cell surface cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031528 microvillus membrane cellular_component
GO:0001530 lipopolysaccharide binding molecular_function
GO:0001786 phosphatidylserine binding molecular_function
GO:0001875 lipopolysaccharide receptor activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005215 transporter activity molecular_function
GO:0005545 1-phosphatidylinositol binding molecular_function
GO:0008035 high-density lipoprotein particle binding molecular_function
GO:0030169 low-density lipoprotein particle binding molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0034186 apolipoprotein A-I binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0070506 high-density lipoprotein particle receptor activity molecular_function