activin A receptor, type IIA

Symbol

ACVR2A (may also be known as: None)

Organism

Human

Description

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Orthologs

SymbolSpecies
acvr2aa Danio rerio
Acvr2a Mus musculus
Acvr2a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2978 Gene expression of ACVR2A increases with age Molecular skin Human ACVR2A —

GO Terms

GO IDGO TermGO Category
GO:0001702 gastrulation with mouth forming second biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0007283 spermatogenesis biological_process
GO:0007368 determination of left/right symmetry biological_process
GO:0007498 mesoderm development biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0010033 response to organic substance biological_process
GO:0030501 positive regulation of bone mineralization biological_process
GO:0030509 BMP signaling pathway biological_process
GO:0030510 regulation of BMP signaling pathway biological_process
GO:0032924 activin receptor signaling pathway biological_process
GO:0032927 positive regulation of activin receptor signaling pathway biological_process
GO:0042713 sperm ejaculation biological_process
GO:0043084 penile erection biological_process
GO:0045648 positive regulation of erythrocyte differentiation biological_process
GO:0045669 positive regulation of osteoblast differentiation biological_process
GO:0046881 positive regulation of follicle-stimulating hormone secretion biological_process
GO:0048706 embryonic skeletal system development biological_process
GO:0050999 regulation of nitric-oxide synthase activity biological_process
GO:0060011 Sertoli cell proliferation biological_process
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0034673 inhibin-betaglycan-ActRII complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0004675 transmembrane receptor protein serine/threonine kinase activity molecular_function
GO:0004702 receptor signaling protein serine/threonine kinase activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0005024 transforming growth factor beta-activated receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0015026 coreceptor activity molecular_function
GO:0016362 activin receptor activity, type II molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function
GO:0017002 activin-activated receptor activity molecular_function
GO:0019838 growth factor binding molecular_function
GO:0043621 protein self-association molecular_function
GO:0046872 metal ion binding molecular_function
GO:0048185 activin binding molecular_function
GO:0048186 inhibin beta-A binding molecular_function
GO:0048187 inhibin beta-B binding molecular_function