pre-mRNA processing factor 3
Symbol
PRPF3
(may also be known as: None)
Organism
Human
Description
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| prp-3 | Caenorhabditis elegans | |
| Prp3 | Drosophila melanogaster | |
| prpf3 | Danio rerio | |
| Prpf3 | Mus musculus | |
| Prpf3 | Rattus norvegicus | |
| PRP3 | Saccharomyces cerevisiae | |
| SPAC29E6.02 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000375 | RNA splicing, via transesterification reactions | biological_process | |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0006397 | mRNA processing | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005681 | spliceosomal complex | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0015030 | Cajal body | cellular_component | |
| GO:0016607 | nuclear speck | cellular_component | |
| GO:0030529 | ribonucleoprotein complex | cellular_component | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |