CD1c molecule

Symbol

CD1C (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3037 Gene expression of CD1C decreases with age Molecular skin Human CD1C —

GO Terms

GO IDGO TermGO Category
GO:0002286 T cell activation involved in immune response biological_process
GO:0006955 immune response biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0030883 endogenous lipid antigen binding molecular_function
GO:0030884 exogenous lipid antigen binding molecular_function
GO:0051861 glycolipid binding molecular_function
GO:0071723 lipopeptide binding molecular_function