CD1b molecule

Symbol

CD1B (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3036 Gene expression of CD1B decreases with age Molecular skin Human CD1B —

GO Terms

GO IDGO TermGO Category
GO:0006955 immune response biological_process
GO:0019882 antigen processing and presentation biological_process
GO:0005765 lysosomal membrane cellular_component
GO:0005768 endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0005515 protein binding molecular_function