DIRAS family, GTP-binding RAS-like 3

Symbol

DIRAS3 (may also be known as: None)

Organism

Human

Description

This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. [provided by RefSeq, Oct 2010]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3526 Gene expression of DIRAS3 decreases with age Molecular skin Human DIRAS3 —

GO Terms

GO IDGO TermGO Category
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0006184 GTP catabolic process biological_process
GO:0006349 regulation of gene expression by genetic imprinting biological_process
GO:0007165 signal transduction biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0005886 plasma membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function