cell division cycle 16

Symbol

CDC16 (may also be known as: None)

Organism

Human

Description

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
emb-27 Caenorhabditis elegans
cdc16 Drosophila melanogaster
cdc16 Danio rerio
Cdc16 Mus musculus
Cdc16 Rattus norvegicus
CDC16 Saccharomyces cerevisiae
cut9 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3511 Gene expression of CDC16 increases with age Molecular skin Human CDC16 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0007067 mitosis biological_process
GO:0007088 regulation of mitosis biological_process
GO:0007094 mitotic cell cycle spindle assembly checkpoint biological_process
GO:0008283 cell proliferation biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0051301 cell division biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0070979 protein K11-linked ubiquitination biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005680 anaphase-promoting complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005819 spindle cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005876 spindle microtubule cellular_component
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function