period circadian clock 3
Symbol
PER3
(may also be known as: None)
Organism
Human
Description
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| per | Drosophila melanogaster | |
| per3 | Danio rerio | |
| Per3 | Mus musculus | |
| Per3 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2851 | Gene expression of PER3 decreases with age | Molecular | adipose tissue | Human | PER3 | — |
GO Terms
| GO ID | GO Term | GO Category |
|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process |
| GO:0007623 | circadian rhythm | biological_process |
| GO:0005634 | nucleus | cellular_component |
| GO:0005737 | cytoplasm | cellular_component |
| GO:0004871 | signal transducer activity | molecular_function |