aldo-keto reductase family 1, member C3


AKR1C3 (may also be known as: None)




This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0002138 retinoic acid biosynthetic process biological_process
GO:0006693 prostaglandin metabolic process biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007584 response to nutrient biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0008584 male gonad development biological_process
GO:0009267 cellular response to starvation biological_process
GO:0010942 positive regulation of cell death biological_process
GO:0016488 farnesol catabolic process biological_process
GO:0016999 antibiotic metabolic process biological_process
GO:0030216 keratinocyte differentiation biological_process
GO:0034614 cellular response to reactive oxygen species biological_process
GO:0034694 response to prostaglandin stimulus biological_process
GO:0042448 progesterone metabolic process biological_process
GO:0042574 retinal metabolic process biological_process
GO:0044259 multicellular organismal macromolecule metabolic process biological_process
GO:0048385 regulation of retinoic acid receptor signaling pathway biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0061370 testosterone biosynthetic process biological_process
GO:0071276 cellular response to cadmium ion biological_process
GO:0071277 cellular response to calcium ion biological_process
GO:0071379 cellular response to prostaglandin stimulus biological_process
GO:0071384 cellular response to corticosteroid stimulus biological_process
GO:0071395 cellular response to jasmonic acid stimulus biological_process
GO:2000224 regulation of testosterone biosynthetic process biological_process
GO:2000353 positive regulation of endothelial cell apoptosis biological_process
GO:2000379 positive regulation of reactive oxygen species metabolic process biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0001758 retinal dehydrogenase activity molecular_function
GO:0004032 alditol:NADP+ 1-oxidoreductase activity molecular_function
GO:0004033 aldo-keto reductase (NADP) activity molecular_function
GO:0004745 retinol dehydrogenase activity molecular_function
GO:0004958 prostaglandin F receptor activity molecular_function
GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor molecular_function
GO:0018636 phenanthrene 9,10-monooxygenase activity molecular_function
GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity molecular_function
GO:0045550 geranylgeranyl reductase activity molecular_function
GO:0045703 ketoreductase activity molecular_function
GO:0047017 prostaglandin-F synthase activity molecular_function
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity molecular_function
GO:0047023 androsterone dehydrogenase activity molecular_function
GO:0047026 androsterone dehydrogenase (A-specific) activity molecular_function
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity molecular_function
GO:0047086 ketosteroid monooxygenase activity molecular_function
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity molecular_function
GO:0047718 indanol dehydrogenase activity molecular_function
GO:0047787 delta4-3-oxosteroid 5beta-reductase activity molecular_function
GO:0050327 testosterone 17-beta-dehydrogenase (NAD+) activity molecular_function