aldo-keto reductase family 1, member C3

Symbol

AKR1C3 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2428	aldo-keto reductase family 1; member C3 decreases with age	Molecular	dermis	Human	AKR1C3	19.3% Decrease DNA Methylation
DAA3496	Gene expression of AKR1C3 decreases with age	Molecular	skin	Human	AKR1C3	—

First
Last

GO Terms

GO ID	GO Term	GO Category
GO:0000060	protein import into nucleus, translocation	biological_process
GO:0002138	retinoic acid biosynthetic process	biological_process
GO:0006693	prostaglandin metabolic process	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	biological_process
GO:0007584	response to nutrient	biological_process
GO:0008202	steroid metabolic process	biological_process
GO:0008284	positive regulation of cell proliferation	biological_process
GO:0008584	male gonad development	biological_process
GO:0009267	cellular response to starvation	biological_process
GO:0010942	positive regulation of cell death	biological_process
GO:0016488	farnesol catabolic process	biological_process
GO:0016999	antibiotic metabolic process	biological_process
GO:0030216	keratinocyte differentiation	biological_process
GO:0034614	cellular response to reactive oxygen species	biological_process
GO:0034694	response to prostaglandin stimulus	biological_process
GO:0042448	progesterone metabolic process	biological_process
GO:0042574	retinal metabolic process	biological_process
GO:0044259	multicellular organismal macromolecule metabolic process	biological_process
GO:0048385	regulation of retinoic acid receptor signaling pathway	biological_process
GO:0051897	positive regulation of protein kinase B signaling cascade	biological_process
GO:0055114	oxidation-reduction process	biological_process
GO:0061370	testosterone biosynthetic process	biological_process
GO:0071276	cellular response to cadmium ion	biological_process
GO:0071277	cellular response to calcium ion	biological_process
GO:0071379	cellular response to prostaglandin stimulus	biological_process
GO:0071384	cellular response to corticosteroid stimulus	biological_process
GO:0071395	cellular response to jasmonic acid stimulus	biological_process
GO:2000224	regulation of testosterone biosynthetic process	biological_process
GO:2000353	positive regulation of endothelial cell apoptosis	biological_process
GO:2000379	positive regulation of reactive oxygen species metabolic process	biological_process
GO:0005622	intracellular	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0001758	retinal dehydrogenase activity	molecular_function
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	molecular_function
GO:0004033	aldo-keto reductase (NADP) activity	molecular_function
GO:0004745	retinol dehydrogenase activity	molecular_function
GO:0004958	prostaglandin F receptor activity	molecular_function
GO:0016655	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	molecular_function
GO:0018636	phenanthrene 9,10-monooxygenase activity	molecular_function
GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	molecular_function
GO:0045550	geranylgeranyl reductase activity	molecular_function
GO:0045703	ketoreductase activity	molecular_function
GO:0047017	prostaglandin-F synthase activity	molecular_function
GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	molecular_function
GO:0047023	androsterone dehydrogenase activity	molecular_function
GO:0047026	androsterone dehydrogenase (A-specific) activity	molecular_function
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	molecular_function
GO:0047086	ketosteroid monooxygenase activity	molecular_function
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	molecular_function
GO:0047718	indanol dehydrogenase activity	molecular_function
GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	molecular_function
GO:0050327	testosterone 17-beta-dehydrogenase (NAD+) activity	molecular_function
▼ Show more GO terms