pyridoxal (pyridoxine, vitamin B6) kinase
Symbol
PDXK
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| F57C9.1 | Caenorhabditis elegans | |
| CG34455-RC | Drosophila melanogaster | |
| pdxkb | Danio rerio | |
| Pdxk | Mus musculus | |
| RGD1566085 | Rattus norvegicus | |
| BUD16 | Saccharomyces cerevisiae | |
| SPAC6F6.11c | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006766 | vitamin metabolic process | biological_process | |
| GO:0006767 | water-soluble vitamin metabolic process | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0009443 | pyridoxal 5'-phosphate salvage | biological_process | |
| GO:0042816 | vitamin B6 metabolic process | biological_process | |
| GO:0042823 | pyridoxal phosphate biosynthetic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0000287 | magnesium ion binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0008478 | pyridoxal kinase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |
| GO:0030170 | pyridoxal phosphate binding | molecular_function | |
| GO:0030955 | potassium ion binding | molecular_function | |
| GO:0031402 | sodium ion binding | molecular_function | |
| GO:0031403 | lithium ion binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |