protein inhibitor of activated STAT, 1

Symbol

PIAS1 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pias1 Danio rerio
Pias1 Mus musculus
Pias1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3493 Gene expression of PIAS1 increases with age Molecular skin Human PIAS1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0007259 JAK-STAT cascade biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0030521 androgen receptor signaling pathway biological_process
GO:0033235 positive regulation of protein sumoylation biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0060333 interferon-gamma-mediated signaling pathway biological_process
GO:0060334 regulation of interferon-gamma-mediated signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0016607 nuclear speck cellular_component
GO:0003676 nucleic acid binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003713 transcription coactivator activity molecular_function
GO:0003714 transcription corepressor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0019789 SUMO ligase activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050681 androgen receptor binding molecular_function