capping protein (actin filament), gelsolin-like
Symbol
CAPG
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| si:ch211-114c12.4 | Danio rerio | |
| Capg | Mus musculus | |
| Capg | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2411 | gelsolin-like capping protein decreases with age | Molecular | dermis | Human | CAPG | 20.1% Decrease DNA Methylation | |
| DAA2460 | gelsolin-like capping protein decreases with age | Molecular | mesenchymal stem cell | Human | CAPG | 19.3% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006461 | protein complex assembly | biological_process | |
| GO:0030031 | cell projection assembly | biological_process | |
| GO:0051016 | barbed-end actin filament capping | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0008290 | F-actin capping protein complex | cellular_component | |
| GO:0031965 | nuclear membrane | cellular_component | |
| GO:0042470 | melanosome | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |