queuine tRNA-ribosyltransferase 1
Symbol
QTRT1
(may also be known as: None)
Organism
Human
Description
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| tgt-1 | Caenorhabditis elegans | |
| Tgt | Drosophila melanogaster | |
| qtrt1 | Danio rerio | |
| Qtrt1 | Mus musculus | |
| Qtrt1 | Rattus norvegicus | |
| SPAC1687.19c | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006400 | tRNA modification | biological_process | |
| GO:0008616 | queuosine biosynthetic process | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005840 | ribosome | cellular_component | |
| GO:0008479 | queuine tRNA-ribosyltransferase activity | molecular_function | |
| GO:0016740 | transferase activity | molecular_function | |
| GO:0016757 | transferase activity, transferring glycosyl groups | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |