syncoilin, intermediate filament protein
Symbol
SYNC
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| sync | Danio rerio | |
| Sync | Mus musculus | |
| Sync | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2389 | syncoilin; intermediate filament 1 decreases with age | Molecular | dermis | Human | SYNC | 16.0% Decrease DNA Methylation | |
| DAA2438 | syncoilin; intermediate filament 1 increases with age | Molecular | mesenchymal stem cell | Human | SYNC | 21.4% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0045103 | intermediate filament-based process | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0005882 | intermediate filament | cellular_component | |
| GO:0030018 | Z disc | cellular_component | |
| GO:0031594 | neuromuscular junction | cellular_component | |
| GO:0042383 | sarcolemma | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0005198 | structural molecule activity | molecular_function | |