N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)


NPL (may also be known as: None)




This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]


npl Danio rerio
Npl Mus musculus
Npl Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0008747 N-acetylneuraminate lyase activity molecular_function
GO:0016829 lyase activity molecular_function