sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Symbol
SEMA3B
(may also be known as: None)
Organism
Human
Description
The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| si:ch211-106g4.2 | Danio rerio | |
| Sema3b | Mus musculus | |
| Sema3b | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2448 | semaphorin 3B isoform 2 precursor increases with age | Molecular | mesenchymal stem cell | Human | SEMA3B | 19.1% Increase DNA Methylation | |
| DAA2399 | semaphorin 3B isoform 2 precursor increases with age | Molecular | dermis | Human | SEMA3B | 16.1% Increase DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |