zinc finger and BTB domain containing 16

Symbol

ZBTB16 (may also be known as: None)

Organism

Human

Description

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
zbtb16a Danio rerio
Zbtb16 Mus musculus
Zbtb16 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2842 Gene expression of ZBTB16 decreases with age Molecular adipose tissue Human ZBTB16 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1392 zinc finger and BTB domain containing 16 Molecular hippocampus Mouse Zbtb16 2.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001501 skeletal system development biological_process
GO:0001823 mesonephros development biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006915 apoptotic process biological_process
GO:0007417 central nervous system development biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0030097 hemopoiesis biological_process
GO:0030099 myeloid cell differentiation biological_process
GO:0032332 positive regulation of chondrocyte differentiation biological_process
GO:0035116 embryonic hindlimb morphogenesis biological_process
GO:0035136 forelimb morphogenesis biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0045600 positive regulation of fat cell differentiation biological_process
GO:0045638 negative regulation of myeloid cell differentiation biological_process
GO:0045778 positive regulation of ossification biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048133 male germ-line stem cell division biological_process
GO:0051216 cartilage development biological_process
GO:0061036 positive regulation of cartilage development biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0016604 nuclear body cellular_component
GO:0016605 PML body cellular_component
GO:0016607 nuclear speck cellular_component
GO:0017053 transcriptional repressor complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046872 metal ion binding molecular_function