wingless-type MMTV integration site family, member 3

Symbol

WNT3 (may also be known as: None)

Organism

Human

Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
wnt3 Danio rerio
Wnt3 Mus musculus
Wnt3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3459 Gene expression of WNT3 increases with age Molecular skin Human WNT3 —

GO Terms

GO IDGO TermGO Category
GO:0000902 cell morphogenesis biological_process
GO:0001707 mesoderm formation biological_process
GO:0007165 signal transduction biological_process
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007411 axon guidance biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0009880 embryonic pattern specification biological_process
GO:0009948 anterior/posterior axis specification biological_process
GO:0009950 dorsal/ventral axis specification biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0030182 neuron differentiation biological_process
GO:0030917 midbrain-hindbrain boundary development biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0035116 embryonic hindlimb morphogenesis biological_process
GO:0042472 inner ear morphogenesis biological_process
GO:0044338 canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation biological_process
GO:0044339 canonical Wnt receptor signaling pathway involved in osteoblast differentiation biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0048697 positive regulation of collateral sprouting in absence of injury biological_process
GO:0048843 negative regulation of axon extension involved in axon guidance biological_process
GO:0060064 Spemann organizer formation at the anterior end of the primitive streak biological_process
GO:0060070 canonical Wnt receptor signaling pathway biological_process
GO:0060173 limb development biological_process
GO:0060174 limb bud formation biological_process
GO:0060323 head morphogenesis biological_process
GO:0061180 mammary gland epithelium development biological_process
GO:0071300 cellular response to retinoic acid biological_process
GO:0071425 hemopoietic stem cell proliferation biological_process
GO:0005576 extracellular region cellular_component
GO:0005578 proteinaceous extracellular matrix cellular_component
GO:0005615 extracellular space cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005769 early endosome cellular_component
GO:0005770 late endosome cellular_component
GO:0005886 plasma membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0005109 frizzled binding molecular_function
GO:0005110 frizzled-2 binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0048018 receptor agonist activity molecular_function