vascular endothelial growth factor C
Symbol
VEGFC
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| vegfc | Danio rerio | |
| Vegfc | Mus musculus | |
| Vegfc | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2841 | Gene expression of VEGFC increases with age | Molecular | adipose tissue | Human | VEGFC | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001525 | angiogenesis | biological_process | |
| GO:0002052 | positive regulation of neuroblast proliferation | biological_process | |
| GO:0002576 | platelet degranulation | biological_process | |
| GO:0006929 | substrate-dependent cell migration | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007596 | blood coagulation | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0009887 | organ morphogenesis | biological_process | |
| GO:0016331 | morphogenesis of embryonic epithelium | biological_process | |
| GO:0030154 | cell differentiation | biological_process | |
| GO:0030168 | platelet activation | biological_process | |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | biological_process | |
| GO:0031954 | positive regulation of protein autophosphorylation | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | biological_process | |
| GO:0045776 | negative regulation of blood pressure | biological_process | |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | biological_process | |
| GO:0050679 | positive regulation of epithelial cell proliferation | biological_process | |
| GO:0050714 | positive regulation of protein secretion | biological_process | |
| GO:0050918 | positive chemotaxis | biological_process | |
| GO:0050930 | induction of positive chemotaxis | biological_process | |
| GO:0051781 | positive regulation of cell division | biological_process | |
| GO:0060754 | positive regulation of mast cell chemotaxis | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0031093 | platelet alpha granule lumen | cellular_component | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008083 | growth factor activity | molecular_function | |
| GO:0042056 | chemoattractant activity | molecular_function | |
| GO:0043185 | vascular endothelial growth factor receptor 3 binding | molecular_function | |