upstream binding transcription factor, RNA polymerase I

Symbol

UBTF (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Orthologs

Symbol	Species
ubtf	Danio rerio
Ubtf	Mus musculus
Ubtf	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA2839	Gene expression of UBTF increases with age	Molecular	adipose tissue	Human	UBTF	—

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GO Terms

GO ID	GO Term	GO Category
GO:0000183	chromatin silencing at rDNA	biological_process
GO:0006356	regulation of transcription from RNA polymerase I promoter	biological_process
GO:0006360	transcription from RNA polymerase I promoter	biological_process
GO:0006361	transcription initiation from RNA polymerase I promoter	biological_process
GO:0006362	transcription elongation from RNA polymerase I promoter	biological_process
GO:0006363	termination of RNA polymerase I transcription	biological_process
GO:0010467	gene expression	biological_process
GO:0045943	positive regulation of transcription from RNA polymerase I promoter	biological_process
GO:0005634	nucleus	cellular_component
GO:0005654	nucleoplasm	cellular_component
GO:0005730	nucleolus	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0005515	protein binding	molecular_function