twist family bHLH transcription factor 1


TWIST1 (may also be known as: None)




Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]


lin-32 Caenorhabditis elegans
Fer2 Drosophila melanogaster
Twist1 Mus musculus
Twist1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001503 ossification biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001764 neuron migration biological_process
GO:0001843 neural tube closure biological_process
GO:0003180 aortic valve morphogenesis biological_process
GO:0003183 mitral valve morphogenesis biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006915 apoptotic process biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007517 muscle organ development biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0010718 positive regulation of epithelial to mesenchymal transition biological_process
GO:0014067 negative regulation of phosphatidylinositol 3-kinase cascade biological_process
GO:0030500 regulation of bone mineralization biological_process
GO:0032000 positive regulation of fatty acid beta-oxidation biological_process
GO:0032720 negative regulation of tumor necrosis factor production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0033128 negative regulation of histone phosphorylation biological_process
GO:0035067 negative regulation of histone acetylation biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0035116 embryonic hindlimb morphogenesis biological_process
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway biological_process
GO:0042473 outer ear morphogenesis biological_process
GO:0042733 embryonic digit morphogenesis biological_process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0045668 negative regulation of osteoblast differentiation biological_process
GO:0045766 positive regulation of angiogenesis biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048642 negative regulation of skeletal muscle tissue development biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0060363 cranial suture morphogenesis biological_process
GO:0060900 embryonic camera-type eye formation biological_process
GO:0061029 eyelid development in camera-type eye biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0071639 positive regulation of monocyte chemotactic protein-1 production biological_process
GO:2000147 positive regulation of cell motility biological_process
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity biological_process
GO:2000679 positive regulation of transcription regulatory region DNA binding biological_process
GO:2000773 negative regulation of cellular senescence biological_process
GO:2000778 positive regulation of interleukin-6 secretion biological_process
GO:2000780 negative regulation of double-strand break repair biological_process
GO:2000793 cell proliferation involved in heart valve development biological_process
GO:0005634 nucleus cellular_component
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043425 bHLH transcription factor binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0070888 E-box binding molecular_function