twist family bHLH transcription factor 1

Symbol

TWIST1 (may also be known as: None)

Organism

Human

Description

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lin-32 Caenorhabditis elegans
Fer2 Drosophila melanogaster
Twist1 Mus musculus
Twist1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3450 Gene expression of TWIST1 decreases with age Molecular skin Human TWIST1 —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001503 ossification biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001764 neuron migration biological_process
GO:0001843 neural tube closure biological_process
GO:0003180 aortic valve morphogenesis biological_process
GO:0003183 mitral valve morphogenesis biological_process
GO:0006366 transcription from RNA polymerase II promoter biological_process
GO:0006915 apoptotic process biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007517 muscle organ development biological_process
GO:0010628 positive regulation of gene expression biological_process
GO:0010718 positive regulation of epithelial to mesenchymal transition biological_process
GO:0014067 negative regulation of phosphatidylinositol 3-kinase cascade biological_process
GO:0030500 regulation of bone mineralization biological_process
GO:0032000 positive regulation of fatty acid beta-oxidation biological_process
GO:0032720 negative regulation of tumor necrosis factor production biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0033128 negative regulation of histone phosphorylation biological_process
GO:0035067 negative regulation of histone acetylation biological_process
GO:0035115 embryonic forelimb morphogenesis biological_process
GO:0035116 embryonic hindlimb morphogenesis biological_process
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway biological_process
GO:0042473 outer ear morphogenesis biological_process
GO:0042733 embryonic digit morphogenesis biological_process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0045668 negative regulation of osteoblast differentiation biological_process
GO:0045766 positive regulation of angiogenesis biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0048642 negative regulation of skeletal muscle tissue development biological_process
GO:0048701 embryonic cranial skeleton morphogenesis biological_process
GO:0060363 cranial suture morphogenesis biological_process
GO:0060900 embryonic camera-type eye formation biological_process
GO:0061029 eyelid development in camera-type eye biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0071639 positive regulation of monocyte chemotactic protein-1 production biological_process
GO:2000147 positive regulation of cell motility biological_process
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity biological_process
GO:2000679 positive regulation of transcription regulatory region DNA binding biological_process
GO:2000773 negative regulation of cellular senescence biological_process
GO:2000778 positive regulation of interleukin-6 secretion biological_process
GO:2000780 negative regulation of double-strand break repair biological_process
GO:2000793 cell proliferation involved in heart valve development biological_process
GO:0005634 nucleus cellular_component
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043425 bHLH transcription factor binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0070888 E-box binding molecular_function