translocated promoter region, nuclear basket protein
Symbol
TPR
(may also be known as: None)
Organism
Human
Description
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| npp-21 | Caenorhabditis elegans | |
| Mtor | Drosophila melanogaster | |
| tprb | Danio rerio | |
| Tpr | Mus musculus | |
| Tpr | Rattus norvegicus | |
| MLP2 | Saccharomyces cerevisiae | |
| nup211 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | biological_process | |
| GO:0006434 | seryl-tRNA aminoacylation | biological_process | |
| GO:0006606 | protein import into nucleus | biological_process | |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | biological_process | |
| GO:0008645 | hexose transport | biological_process | |
| GO:0010827 | regulation of glucose transport | biological_process | |
| GO:0015031 | protein transport | biological_process | |
| GO:0015758 | glucose transport | biological_process | |
| GO:0016032 | viral reproduction | biological_process | |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0051028 | mRNA transport | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0000776 | kinetochore | cellular_component | |
| GO:0000777 | condensed chromosome kinetochore | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005635 | nuclear envelope | cellular_component | |
| GO:0005643 | nuclear pore | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005694 | chromosome | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0031965 | nuclear membrane | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0004828 | serine-tRNA ligase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |