tumor protein p53

Symbol

TP53

Organism

Human

Description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Orthologs

SymbolSpecies
tp53 Danio rerio
Tp53 Mus musculus
Tp53 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA677 Proportion of apoptotic cells may be increased Physiological mesenchymal stem cell Human TP53 —

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000075 cell cycle checkpoint biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000733 DNA strand renaturation biological_process
GO:0001701 in utero embryonic development biological_process
GO:0001756 somitogenesis biological_process
GO:0001836 release of cytochrome c from mitochondria biological_process
GO:0002309 T cell proliferation involved in immune response biological_process
GO:0002326 B cell lineage commitment biological_process
GO:0002360 T cell lineage commitment biological_process
GO:0006284 base-excision repair biological_process
GO:0006289 nucleotide-excision repair biological_process
GO:0006302 double-strand break repair biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006461 protein complex assembly biological_process
GO:0006915 apoptotic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest biological_process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator biological_process
GO:0006983 ER overload response biological_process
GO:0007049 cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007265 Ras protein signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0007369 gastrulation biological_process
GO:0007406 negative regulation of neuroblast proliferation biological_process
GO:0007417 central nervous system development biological_process
GO:0007569 cell aging biological_process
GO:0007596 blood coagulation biological_process
GO:0008104 protein localization biological_process
GO:0008156 negative regulation of DNA replication biological_process
GO:0008283 cell proliferation biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008340 determination of adult lifespan biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0008635 activation of caspase activity by cytochrome c biological_process
GO:0009303 rRNA transcription biological_process
GO:0009651 response to salt stress biological_process
GO:0009792 embryo development ending in birth or egg hatching biological_process
GO:0010165 response to X-ray biological_process
GO:0010332 response to gamma radiation biological_process
GO:0030154 cell differentiation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030330 DNA damage response, signal transduction by p53 class mediator biological_process
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway biological_process
GO:0031065 positive regulation of histone deacetylation biological_process
GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint biological_process
GO:0033077 T cell differentiation in thymus biological_process
GO:0034613 cellular protein localization biological_process
GO:0034644 cellular response to UV biological_process
GO:0035264 multicellular organism growth biological_process
GO:0035690 cellular response to drug biological_process
GO:0042149 cellular response to glucose starvation biological_process
GO:0042493 response to drug biological_process
GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043525 positive regulation of neuron apoptosis biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046677 response to antibiotic biological_process
GO:0046902 regulation of mitochondrial membrane permeability biological_process
GO:0048147 negative regulation of fibroblast proliferation biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0050790 regulation of catalytic activity biological_process
GO:0051097 negative regulation of helicase activity biological_process
GO:0051262 protein tetramerization biological_process
GO:0051276 chromosome organization biological_process
GO:0051726 regulation of cell cycle biological_process
GO:0070245 positive regulation of thymocyte apoptosis biological_process
GO:0071158 positive regulation of cell cycle arrest biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0071479 cellular response to ionizing radiation biological_process
GO:0072332 signal transduction by p53 class mediator resulting in induction of apoptosis biological_process
GO:0090343 positive regulation of cell aging biological_process
GO:0090399 replicative senescence biological_process
GO:0090403 oxidative stress-induced premature senescence biological_process
GO:2000379 positive regulation of reactive oxygen species metabolic process biological_process
GO:0000785 chromatin cellular_component
GO:0000790 nuclear chromatin cellular_component
GO:0005626 insoluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005657 replication fork cellular_component
GO:0005669 transcription factor TFIID complex cellular_component
GO:0005678 chromatin assembly complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005829 cytosol cellular_component
GO:0016363 nuclear matrix cellular_component
GO:0016604 nuclear body cellular_component
GO:0016605 PML body cellular_component
GO:0043234 protein complex cellular_component
GO:0000739 DNA strand annealing activity molecular_function
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription molecular_function
GO:0001085 RNA polymerase II transcription factor binding molecular_function
GO:0002020 protease binding molecular_function
GO:0002039 p53 binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003684 damaged DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0005507 copper ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function
GO:0035033 histone deacetylase regulator activity molecular_function
GO:0035035 histone acetyltransferase binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0051087 chaperone binding molecular_function
GO:0051721 protein phosphatase 2A binding molecular_function
GO:0070215 MDM2 binding molecular_function