tumor necrosis factor

Symbol

TNF

Organism

Human

Orthologs

SymbolSpecies
Tnf Mus musculus
Tnf Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1208 Blood TNF-alpha level increase Physiological plasma Human TNF —
DAA1987 Loss of CpG methylation in the promoter of TNF Molecular macrophage, leukocyte Human TNF —

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0000165 MAPKKK cascade biological_process
GO:0000185 activation of MAPKKK activity biological_process
GO:0000187 activation of MAPK activity biological_process
GO:0001666 response to hypoxia biological_process
GO:0001775 cell activation biological_process
GO:0001819 positive regulation of cytokine production biological_process
GO:0001932 regulation of protein phosphorylation biological_process
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0002037 negative regulation of L-glutamate transport biological_process
GO:0002439 chronic inflammatory response to antigenic stimulus biological_process
GO:0002740 negative regulation of cytokine secretion involved in immune response biological_process
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus biological_process
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin biological_process
GO:0003009 skeletal muscle contraction biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006927 transformed cell apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0006959 humoral immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007275 multicellular organismal development biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0008625 induction of apoptosis via death domain receptors biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009615 response to virus biological_process
GO:0009651 response to salt stress biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0010888 negative regulation of lipid storage biological_process
GO:0010940 positive regulation of necrotic cell death biological_process
GO:0014823 response to activity biological_process
GO:0019722 calcium-mediated signaling biological_process
GO:0030198 extracellular matrix organization biological_process
GO:0030730 sequestering of triglyceride biological_process
GO:0031334 positive regulation of protein complex assembly biological_process
GO:0031622 positive regulation of fever generation biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032715 negative regulation of interleukin-6 production biological_process
GO:0032722 positive regulation of chemokine production biological_process
GO:0032729 positive regulation of interferon-gamma production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032800 receptor biosynthetic process biological_process
GO:0033138 positive regulation of peptidyl-serine phosphorylation biological_process
GO:0033209 tumor necrosis factor-mediated signaling pathway biological_process
GO:0034116 positive regulation of heterotypic cell-cell adhesion biological_process
GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process
GO:0042493 response to drug biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043068 positive regulation of programmed cell death biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043243 positive regulation of protein complex disassembly biological_process
GO:0043406 positive regulation of MAP kinase activity biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043525 positive regulation of neuron apoptosis biological_process
GO:0044130 negative regulation of growth of symbiont in host biological_process
GO:0045071 negative regulation of viral genome replication biological_process
GO:0045080 positive regulation of chemokine biosynthetic process biological_process
GO:0045123 cellular extravasation biological_process
GO:0045416 positive regulation of interleukin-8 biosynthetic process biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0045599 negative regulation of fat cell differentiation biological_process
GO:0045670 regulation of osteoclast differentiation biological_process
GO:0045672 positive regulation of osteoclast differentiation biological_process
GO:0045840 positive regulation of mitosis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0045994 positive regulation of translational initiation by iron biological_process
GO:0046325 negative regulation of glucose import biological_process
GO:0046330 positive regulation of JNK cascade biological_process
GO:0048566 embryonic digestive tract development biological_process
GO:0048661 positive regulation of smooth muscle cell proliferation biological_process
GO:0050715 positive regulation of cytokine secretion biological_process
GO:0050796 regulation of insulin secretion biological_process
GO:0050806 positive regulation of synaptic transmission biological_process
GO:0050830 defense response to Gram-positive bacterium biological_process
GO:0050901 leukocyte tethering or rolling biological_process
GO:0050995 negative regulation of lipid catabolic process biological_process
GO:0051023 regulation of immunoglobulin secretion biological_process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0051222 positive regulation of protein transport biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051533 positive regulation of NFAT protein import into nucleus biological_process
GO:0051798 positive regulation of hair follicle development biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0060555 induction of necroptosis by extracellular signals biological_process
GO:0060557 positive regulation of vitamin D biosynthetic process biological_process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity biological_process
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis biological_process
GO:0060693 regulation of branching involved in salivary gland morphogenesis biological_process
GO:0061048 negative regulation of branching involved in lung morphogenesis biological_process
GO:0070265 necrotic cell death biological_process
GO:0070374 positive regulation of ERK1 and ERK2 cascade biological_process
GO:0071230 cellular response to amino acid stimulus biological_process
GO:0071316 cellular response to nicotine biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:0071803 positive regulation of podosome assembly biological_process
GO:0097191 extrinsic apoptotic signaling pathway biological_process
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production biological_process
GO:0001891 phagocytic cup cellular_component
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005622 intracellular cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0055037 recycling endosome cellular_component
GO:0002020 protease binding molecular_function
GO:0005125 cytokine activity molecular_function
GO:0005164 tumor necrosis factor receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042802 identical protein binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function